Individual and combined anti-trypanosomal effects of arteether and diminazene aceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats
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Efficacy of repeated doses of diminazene aceturate (Dinazene®) in the treatment of experimental Trypanosoma brucei infection of Albino rats
The efficacy of repeated doses of Dinazene® in Albino rats experimentally infected with Trypanosoma brucei (Gboko strain) was investigated. A total of 30 adult female Albino rats weighing 130-190 g were used for the study. They were assigned to six groups (groups A-F) of five rats each. Groups A-D were infected intraperitoneally with 1.0 × 106 trypanosomes in 400 μL of PBS diluted blood while g...
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The therapeutic efficacy of Cotecxin (Dihydroartemisinin) alone and its combination with diminazene aceturate (Berenil) was studied in rats infected with Federe strain of Trypanosoma brucei brucei. Fifty healthy adult albino rats of both sexes weighing between 100-180g used were divided into five groups (A-E) of 10 rats each. Rats in groups A-D were each infected with T.b. brucei (1x10trypanoso...
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The anti-trypanosomal effects of aqueous extract of the leaf of Ocimum gratissimum were evaluated in both in-vitro and in-vivo studies. The anti-trypanosomal activity of the extract against Trypanosoma brucei was investigated in-vitro. The survival and motility of the trypanosomes were completely inhibited within two hours of incubation in various concentrations of the extract. Parasite surviva...
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The effects of Trypanosoma brucei infection on testicular morphology and function and the changes associated with treatment of infected dogs with diminazene aceturate were studied using fifteen Nigerian adult male dogs. The dogs were randomly assigned into three groups A, B and C consisting of five dogs each. Groups A and B were infected with 1 × 10(6) trypanosomes and group C was the uninfecte...
متن کاملChanges in haematological indices and protein concentrations in Trypanosoma brucei infected rats treated with homidium chloride and diminazene aceturate
Anaemia and immunosuppresion have been shown to be a cardinal feature in African trypanosomosis. In this study, we have evaluated and compared the capacity of two registered veterinary trypanocides Novidium® (homidium chloride) and Berenil® (diminazene aceturate) to reduce haematological and biochemical lesions in rats experimentally infected with T. brucei. Packed cell volume (PCV), lymphocyte...
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ژورنال
عنوان ژورنال: September-2020
سال: 2020
ISSN: 2231-0916,0972-8988
DOI: 10.14202/vetworld.2020.1858-1862